Report

Commercialising Science

21.8.24

High tech lab

Significant real estate lettings tell the story of a country highly attractive to global giants from Apple and Amazon to Moderna and MSD, but which struggles to nurture and retain our own innovative SMEs to scale. This is not to say the UK has an unimpressive record.

According to Beauhurst, 43 unicorns are headquartered in the UK, just under 4% of the ‘global herd’. But eight have exited in recent years having reached mystical creature status, while a number of others have been acquired by overseas companies albeit remaining UK based.

As seen globally, the pace of unicorn creation has slowed in the UK during the post-pandemic period, but more concerning for the UK, success remains focused in the Golden Triangle of Oxford, Cambridge, and London. Globally leading R&D and innovative SMEs are not successfully translating to the growth of knowledge-intensive companies and employment in the vast majority of the country.

While the global investment environment is a factor in the recent slowdown, understanding the underlying domestic barriers to innovative SME growth is crucial for our ability to redirect our economy, which holds such potential.

"Many will start; few will finish strong" 

- GR Blair

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Following a boom in funding during the pandemic period, we have seen investment levels slip away globally. While early stage funding has returned to levels not far short of the pre-pandemic period, later stage fundraising, which effectively makes the important step in the commercialisation of innovation, remains severely suppressed.

“Increased industry competition from international markets and global players is the greatest challenge for our business.”

SME survey response, Bidwells and Censuswide, 2024

This is the area where the UK has historically fallen short relative to competitor countries, a situation made more acute with the global caution in the VC funding market. Nearly £6bn of Series C funds were raised in 2023 in the UK, a quarter of the amount in 2018/19 according to Beauhurst. This was just 27% of total investment in 2023, compared with 40% prior to the pandemic. In the tech sector, for example, the UK has fared worse than many other ecosystems. According to Dealroom, late-stage funding fell 75% compared to the first half of 2022—versus a 51% fall in the US, 58% in Asia, and 64% in France.

Positively, there is an estimated $6.6bn of new VC fund capital raised in the UK waiting to be invested. This has been helped by the arrival of a number of US VC funds into London. However, to achieve a material impact in the economic contribution of the UK’s wall of innovative potential, it will be necessary to see greater late-stage funding, crucially combined with confidence in the UK as a place to scale businesses.

What is needed to achieve this?

In part, it will depend on a greater willingness of start-ups to take the growth leap. Many companies have been making do with relatively generous ‘runways’ of funding from the 2021 and 2022 years before globally base rates made their rapid ascent. However, as this funding starts to run dry and improved confidence is reflected in valuations, it is likely we will see greater demand for funding come forward.

This investment is much needed. During May 2024, Bidwells, with Censuswide, undertook a survey of SMEs operating across a range of scientific areas in the UK, ranging from life sciences, tech, sustainability, automotive, and agri-tech. Over three quarters of these companies were university spinouts. The study finds the availability of capital as the greatest barrier for companies overall, closely followed by their access to talent. However, funding is markedly more of an issue for the smallest companies and those mid-sized, between 50-99 employees.


Greatest barriers to growth

Funding
Access to talent
Property to grow business
Regulation

Source: Bidwells & Censuswide, May 2024

Funding can be fickle

Furthermore, the depth of early-stage funding is not uniform across sectors. The ebb and flow of sentiment will reflect wider economic and political issues, domestic industrial strategy, as well as advances in a particular area. Some sectors are very expensive to scale, which is challenging when funding is less plentiful. Others will depend on confidence that a particular sector will receive political and/or regulatory support for growth.

Currently, sustainability and AI continue to hold strong investor appeal globally, with life sciences slipping back due to values and risk perceptions. This is also being seen in the UK, illustrated by our analysis of Beauhurst fundraising trends. While capital raising by UK companies is down overall, the impact has been more sharply felt in some sectors.

60%

of mid sized (50-99 employees) scientific companies consider finance to be a barrier to growth.

These funding trends inevitably impact the ability of companies to scale. In our survey of SMEs, life science companies report finance to be the greatest barrier to growth, with similar challenges seen in the automotive and tech hardware sectors. In contrast, the energy and environmental sectors are the least concerned about finance, although they are challenged in other ways, particularly access to talent, a point discussed elsewhere in this report.

Similarly, as noted above, some regions appear better able to attract funding and talent than others. Such imbalances tend to be self-reinforcing and underpin future inequality. This imbalance in delivering growth support to innovative companies is an opportunity cost for the country as a whole.

A strategic play for growth

While the UK’s innovative future will depend on liquid and well-funded capital markets, the imbalances in funding suggest a strategic approach to growing and scaling our innovative economy is needed. This is perhaps illustrated by the agri-tech sector, in which the UK has a strong position, exemplified by the growing critical mass in Norwich, which has benefited from some public research funding. The challenge of scaling companies and building clusters of critical mass requires greater commitment, as well as support for strategic links across the country. Virtual clusters can be engineered but cannot be achieved piecemeal.

There is a cost to delaying growth. In addition to funding challenges, over recent years a lack of appropriate science or technical space has seen vested capital sit dormant. This position is being addressed in markets such as Oxford, Cambridge, and London, where lab and other technical floorspace is coming forward, but the challenge of the provision of suitable scientific space persists. However, viability challenges derived from higher finance costs have stalled the delivery of science and technical business space across much of the country. 46% of SMEs in our survey located outside the Golden Triangle report access to property as a key barrier to their growth, compared with 31% of those located within the region.

In our survey, 100% of those businesses occupying the smallest floorspace bracket report a lack of property to be their companies’ greatest barrier to growth. This is also a particular challenge for larger space users in the chemical, industrials, and automotive sectors, which report the lack of suitable business space as their greatest barrier to growth, second only to finance.

Crucially, other specialist space and facilities need to develop in parallel with our SME ecosystem. The evolution of the UK’s science and tech economy will depend on the delivery of data centres, quantum computing facilities, and GMP space. There is little point in developing new innovative therapeutics if the testing and manufacturing go elsewhere in the world.

Not just an ‘SME issue’

These challenges are not, of course, just the preserve of spinouts and start-ups. For mature companies, there is often a very high opportunity cost to investing in innovative ventures, even though returns from innovation investments are dominated by the “transformational realm.”

Crucially, many of the sectors in which these apparently stable mature companies operate are facing an unprecedented period of disruption and change. The failure of innovation in the economy, whether in their own business or among the army of SMEs across specialist sectors on which they depend, will have long-term negative implications that will directly impact shareholder value.

The potential for innovation in the energy and transport sectors is evident. Meanwhile, in the life science sector, large pharma companies have relied on specialist SMEs for R&D in cell, gene, and mRNA technologies to revolutionise medicine. The manufacturing of drugs is being transformed by robotics, and across all such areas, AI is just starting on its path to transforming how science is undertaken.

The economic and social opportunity cost of not supporting UK innovation beyond the idea cannot be contemplated.

Automation and artificial intelligence technologies have the potential to transform industries by streamlining processes and improving efficiency.
SME survey response - Bidwells & Censuswide, 2024

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Get in touch with our team

Sue Foxley

Sue Foxley

Research Director

Sue leads a dynamic programme of research at Bidwells. Working with her colleague Mark Callender, she is particularly focused on the real estate implications of the science and technology sector.

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Mark Callender - higher res

Mark Callendar

Research Partner

Mark was appointed as research partner to focus on high-growth sectors, including renewable energy, science and technology, and natural capital markets.

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